Award details

In vitro synthesis of bone tissue: bioreactor and scaffold design

Reference	E13948
Principal Investigator / Supervisor	Professor James Triffitt
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	NDORMS
Funding type	Research
Value (£)	148,364
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	31/07/2004
Duration	43 months

Abstract

A new approach to generation of bone tissue in vitro by using a novel tissue- scaffold design is proposed. Tissue formation is confined within a nanoporous matrix, and micropores within the scaffold do not become blocked as the tissue is formed, which is a major problem with current porous scaffolds. Our preliminary studies have shown that bone tissue is formed within such a matrix, and scaffolds with nano- and micro-scale porosity have been produced. To more closely approach in vivo conditions, this system will be used to co-culture endothelial cells and osteoblasts and their precursors, as interactions between these cells is crucial for control of bone formation in vivo. By studying the effects of culture conditions and scaffold design on matrix formation and apoptosis, in vitro synthesised bone formation will be optimised and its use as autograft substitute will be assessed in vivo. (Joint with grant 6/E13949.)

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E13949 In vitro synthesis of bone tissue

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