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Assembly of nanoparticle drug delivery systems using novel functional biodegradable block copolymers
Reference
E13897
Principal Investigator / Supervisor
Professor Martin Garnett
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
161,488
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
07/07/2003
Duration
21 months
Abstract
Novel biodegradable polymers with a fatty acyl functional group will be synthesised at CEAC Aston using a range of natural building blocks in an enzyme catalysed reaction. A polyethylene glycol hydrophilic block will be attached to these polyesters using conventional chemical synthesis to produce a diblock copolymer. The copolymers will be assembled into micelle-like nanoparticles at Pharmaceutical Sciences, Nottingham, their characteristics determined (size, stability, morphology, steric stabilisation), and their drug delivery properties (drug incorporation and release, in vivo biodistribution) investigated using dexamethasone. Feedback from the nanoparticle properties will be used to inform the synthesis of further suitable polymers. (Joint with grant 92/E13900.)
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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