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Metabolic control analysis and engineering of the yeast sterol pathway
Reference
E13805
Principal Investigator / Supervisor
Dr Diane Kelly
Co-Investigators /
Co-Supervisors
Professor Douglas Kell
,
Professor Steven Kelly
Institution
Aberystwyth University
Department
Inst of Biological, Environ & Rural Sci
Funding type
Research
Value (£)
250,332
Status
Completed
Type
Research Grant
Start date
01/02/2001
End date
01/02/2004
Duration
36 months
Abstract
The sterol biosynthetic pathway is important in the production not only of sterols, but of steroids and vitamin D and is the main current target for antifungals. Yeast has been used in defining the eukaryote sterol pathway and the full set of genes/enzymes has recently become known. The project will apply metabolic control analysis to sterol biosynthesis. This will involve the use of novel yeast genetic methods and experience of sterol studies in the group of Dr D.E. Kelly and Professor S.L. Kelly and application of metabolic control analysis in collaboration with Professor D.B. Kell.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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