Award details

Registration and compression of proteome gel images

Reference	E13803
Principal Investigator / Supervisor	Professor Douglas Kell
Co-Investigators / Co-Supervisors	Dr Bjorn Alsberg, Mr Jem Rowland, Dr Andrew Woodward
Institution	Aberystwyth University
Department	Inst of Biological, Environ & Rural Sci
Funding type	Research
Value (£)	185,388
Status	Completed
Type	Research Grant
Start date	01/08/2000
End date	01/08/2003
Duration	36 months

Abstract

2D electrophoretic (proteome) gels are imperfectly reproducible. To compare them it is necessary to align them to a reference gel, such that the same proteins appear in the same place, a process known as image registration. Currently this is done manually, which presents a serious bottleneck as this is slow, tedious and subjective. We shall automate this process by exploiting a recently developed approach which has the desirable combined properties of reconstruction, orthogonality, redundancy, locality and linearity. We shall effect its optimal parametrisation. This approach will also allow simultaneous registration and compression of proteome gel images.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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