Award details

Affinity biopolymers for metabolite-responsive fusogenic vesicles

Reference	E13731
Principal Investigator / Supervisor	Professor Nigel Slater
Co-Investigators / Co-Supervisors	Dr M Eccleston
Institution	University of Cambridge
Department	Chemical Engineering and Biotechnology
Funding type	Research
Value (£)	178,096
Status	Completed
Type	Research Grant
Start date	27/11/2000
End date	27/11/2003
Duration	36 months

Abstract

We propose to synthesise biopolymers that provide liposomes with a metabolite responsive destabilisation behaviour. The materials will incorporate two key functions. They will integrate into lipid bilayers by hydrophobic association and change conformation in response to the affinity binding of a metabolite. The consequent shear stress in the bilayer causes its disruption. We propose polymers that respond to different chemical stimuli that alter the charge distribution on the polymer. To demonstrate application we shall synthesise a liposome that is programmed to disrupt when exposed to glucose concentrations typical of those encountered in physiological fluids.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search