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Multigene engineering of mRNA translation initiation in eukaryotic cells for enhanced recombinant protein production
Reference
E13497
Principal Investigator / Supervisor
Dr L Naylor
Co-Investigators /
Co-Supervisors
Professor Christopher Proud
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
174,116
Status
Completed
Type
Research Grant
Start date
17/07/2000
End date
16/02/2006
Duration
67 months
Abstract
By transient and inducible multigene engineering of eukaryotic host cells with mutated forms of proteins which are known to regulate eukaryotic mRNA translation initiation, we aim to overcome translational limitations in order to produce generic expression systems that more efficiently and persistently express proteins encoded by introduced DNA. The outcomes of this research will be 1) the creation of well-characterised multigene expression vectors; 2) novel eukaryotic cell engineering technology for enhanced recombinant protein production; and 3) associated with the above, an understanding of the concerted regulation of the initiation of mRNA translation in eukaryotic cells.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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