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Molecularly imprinted scintillation proximity assay : combinatorial polymer optimisation and high-throughput assay

Reference	E13283
Principal Investigator / Supervisor	Professor Andrew Mayes
Co-Investigators / Co-Supervisors
Institution	University of East Anglia
Department	Chemistry
Funding type	Research
Value (£)	202,776
Status	Completed
Type	Research Grant
Start date	24/07/2000
End date	24/07/2003
Duration	36 months

Abstract

A new platform technology called MISPA is proposed, based on the combination of molecularly imprinted polymers (MIPs) and scintillation proximity assay (SPA). MIPs provide a generic route to robust, selective, high affinity artificial receptors for small molecules. SPA provides a screening technology to measure analyte binding in a simple, automated way. This proposal seeks to: 1) demonstrate the feasibility of combining MIPs with SPA; 2) use MISPA for the combinatorial optimisation of MIPs, leading to a method for the rapid synthesis and selection of MIPS with optimised binding properties for an analyte of interest; and 3) apply the optimised MIPs in a new high-throughput MISPA assay system for measuring analytes in real samples.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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