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The development of a biotransformation system for the synthesis of carbon-fluorine bonds

Reference	E13156
Principal Investigator / Supervisor	Professor David O'Hagan
Co-Investigators / Co-Supervisors
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	202,246
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/01/2004
Duration	45 months

Abstract

A research programme is proposed to investigate the biosynthesis and mechanism of fluorination in Streptomyces cattleya which produces fluoroacetate and 4-fluorothreonine as secondary metabolites. The principal aims are to determine the substrate for the fluorination enzyme, to establish cell free activity for biological fluorination and then to develop an assay and purify the enzyme. It will be relevant to characterise the activity with particular reference to parameters relevant to its biotechnological potential and it is an objective to establish the stereochemical course of the fluorination event.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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