Award details

Exploitation of Bayesian design in steady-state enzyme-ligand binding and catalysis

Reference	E13044
Principal Investigator / Supervisor	Professor Michael Crabbe
Co-Investigators / Co-Supervisors	Dr Steven Gilmour
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	190,444
Status	Completed
Type	Research Grant
Start date	01/10/2000
End date	01/10/2003
Duration	36 months

Abstract

We intend to exploit Bayesian design methods to optimise information retrieval in steady-state enzyme kinetic experiments. The role of randomisation and blocking in deciding on the run order for experiments will be explored, as will sequential design to allow experiments to determine when sufficient data has been obtained in order to verify a particular kinetic model. The specific quantifiable aims of the project are: 1) to develop methods of experimental design in enzyme kinetics which are efficient, valid, and applicable for biochemists; 2) to compare alternative design analytical strategies for fitting non-linear models by computer curvefitting; and 3) to evaluate the robustness of model discrimination for enzyme-ligand kinetics.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search