BBSRC Portfolio Analyser
Award details
Cryogenic force microscopy of biomolecular structure
Reference
E12956
Principal Investigator / Supervisor
Professor Clive Roberts
Co-Investigators /
Co-Supervisors
Professor Martyn Davies
,
Professor Saul Tendler
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
298,773
Status
Completed
Type
Research Grant
Start date
05/06/2000
End date
04/12/2003
Duration
42 months
Abstract
The ultimate attainable resolution of individual biological molecules using conventional scanning force microscopy (SFM) is currently limited by molecular deformation and thermal fluctuations. However, it is proposed that at cryogenic temperatures the resultant increase in molecular stiffness will be sufficient to withstand SFM imaging forces, and hence improve resolution. This application therefore seeks to develop the first European cryogenic biological SFM (cryoSFM), for the study of biomolecular structure at ultra-high spatial resolution. In collaboration with Oxford Instruments and SmithKline Beecham, a cryoAFM instrument will be designed, commissioned, constructed and developed. In addition, using biological samples of academic and industrial interest and relevance, operating procedures for the routine preparation, preservation and imaging of samples will be developed.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search