Award details

Cryogenic force microscopy of biomolecular structure

ReferenceE12956
Principal Investigator / Supervisor Professor Clive Roberts
Co-Investigators /
Co-Supervisors
Professor Martyn Davies, Professor Saul Tendler
Institution University of Nottingham
DepartmentSch of Pharmacy
Funding typeResearch
Value (£) 298,773
StatusCompleted
TypeResearch Grant
Start date 05/06/2000
End date 04/12/2003
Duration42 months

Abstract

The ultimate attainable resolution of individual biological molecules using conventional scanning force microscopy (SFM) is currently limited by molecular deformation and thermal fluctuations. However, it is proposed that at cryogenic temperatures the resultant increase in molecular stiffness will be sufficient to withstand SFM imaging forces, and hence improve resolution. This application therefore seeks to develop the first European cryogenic biological SFM (cryoSFM), for the study of biomolecular structure at ultra-high spatial resolution. In collaboration with Oxford Instruments and SmithKline Beecham, a cryoAFM instrument will be designed, commissioned, constructed and developed. In addition, using biological samples of academic and industrial interest and relevance, operating procedures for the routine preparation, preservation and imaging of samples will be developed.

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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