Award details

Simultaneous fluorescence and topographic imaging of live cells : towards a new and general method for functional imaging

Reference	E12931
Principal Investigator / Supervisor	Professor Yuri Korchev
Co-Investigators / Co-Supervisors	Dr Christopher Edwards, Professor David Klenerman, Professor Max Lab
Institution	Imperial College London
Department	Department of Medicine (Hammersmith)
Funding type	Research
Value (£)	263,532
Status	Completed
Type	Research Grant
Start date	07/06/2000
End date	04/10/2003
Duration	40 months

Abstract

The aim of this research project is to develop a method to rapidly and repetitively image cell membrane components (e.g. receptors) on living cells and follow changes in their distribution, interaction with other cellular components (e.g. second messengers, cytoskeletal elements) and cell morphology after different stimuli and as a function of time. We propose to build a unique high resolution Scanning Microscope which enables 3D mapping of the distribution of active cell plasma membrane components. The apparatus will enable Scanning Surface Laser Confocal/Ion Conductance Microscopy where the surface of a live cell will be optically and topographically visualised in a single scan.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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