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Influence of surface chemistry on the kinetics of adsorption and conformational changes of cell adhesive glycoproteins

Reference	E12709
Principal Investigator / Supervisor	Professor Graham Leggett
Co-Investigators / Co-Supervisors	Professor Peter Gardner
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	149,320
Status	Completed
Type	Research Grant
Start date	12/06/2000
End date	12/06/2003
Duration	36 months

Abstract

Recent studies using self-assembled monolayers have led to clear phenomenological relationships between surface chemical structure and the behaviour of mammalian cells cultured on artificial substrata. However, there is at present no mechanistic explanation for these data. The present proposal seeks to test the hypothesis that relationships between cell attachment and surface chemistry may be explained in terms of the uptake and post- adsorption conformational changes of specific proteins. It is proposed to use a powerful, integrated approach, combining biochemical techniques with physico-chemical methods, to provide a comprehensive understanding of the kinetics of adsorption and post- adsorption conformational changes of key proteins.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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