Award details

Site-specific neuromuscular junction formation via biomimetic engineering

Reference	E12523
Principal Investigator / Supervisor	Professor Kevin Shakesheff
Co-Investigators / Co-Supervisors	Professor Barrie Kellam, Professor David Kendall
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	223,696
Status	Completed
Type	Research Grant
Start date	30/04/2000
End date	30/04/2003
Duration	36 months

Abstract

Many advances in tissue engineering have been founded on the control of cell interactions with polymer scaffold surfaces. However, this approach is not applicable in the engineering of tissues in which cell-to-cell interactions are the vital control mechanism in tissue development. To engineer such complex tissues it is necessary to consider living cells as scaffold materials and to develop methods of surface engineering these 'living scaffolds'. This research programme will investigate the hypothesis that a novel engineering strategy to modify the surfaces of specific cells can be employed to engineer complex tissues in vitro. Specifically, this surface engineering strategy will allow the controlled formation of neuromuscular junctions at specific sites on engineered muscle tissue, resulting in the patterned innervation of regenerated tissues.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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