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Cell cycle and apoptosis regulation in NSO myeloma cell line

Reference	E12417
Principal Investigator / Supervisor	Professor M Al-Rubeai
Co-Investigators / Co-Supervisors	Dr Charles Shuttleworth
Institution	University of Birmingham
Department	Chemical Engineering
Funding type	Research
Value (£)	185,544
Status	Completed
Type	Research Grant
Start date	10/04/2000
End date	26/08/2003
Duration	41 months

Abstract

It is proposed to use a metabolic engineering approach to control proliferation, enhance survival and improve cellular responses to the external environment, by manipulating the pathways which regulate cell cycle progression and cell death. Vectors containing inducible cytostatic and anti-apoptotic genes will be constructed and introduced into myeloma cells. An alternative approach to controlling cell proliferation will also be investigated, using potent and selective chemical inhibitors of cyclin-dependent kinases. In addition, cells will be transfected with inducible antisense cyclinB RNA vector as a further approach to controlling growth rate. The engineered and treated cells will be tested for improved productivity.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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