Award details

Asymmetric hydrogenation of imines: a new target for biocatalysis

Reference	E12135
Principal Investigator / Supervisor	Professor Gillian Stephens
Co-Investigators / Co-Supervisors	Dr John Gardiner
Institution	The University of Manchester
Department	Chem Eng and Analytical Science
Funding type	Research
Value (£)	43,520
Status	Completed
Type	Research Grant
Start date	02/01/2001
End date	02/01/2002
Duration	12 months

Abstract

Novel biocatalytic routes for asymmetric hydrogenation of imines will be developed to provide a wider range of enantiopure alpha-chiral amines as high-value synthetic building blocks for industry. Two strategies will be used to identify the biocatalysts. Firstly, enoate reducing anaerobic bacteria will be screened for cometabolism of imines. Secondly, selective enrichment techniques will be developed to isolate new anaerobes which can grow by using imines as electron acceptors. The conditions for the enrichments will be developed and optimised by using factorial experimental design and modelling to greatly facilitate this process. The primary target for this one year project will be to obtain hydrogenation of one or more synthetic, prochiral imines via either strategy, which will represent a substantial advance in biocatalyst technology. If time permits, the industrial utility of the new biocatalysts will also be assessed by determining catalytic activity, enantioselectivity and substrate specificity.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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