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Immunosensor based on the direct enzymatic degradation of thin films

Reference	E11930
Principal Investigator / Supervisor	Professor Steffi Krause
Co-Investigators / Co-Supervisors	Professor Calum McNeil, Professor Charles Stirling
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	198,914
Status	Completed
Type	Research Grant
Start date	20/10/1999
End date	20/10/2002
Duration	36 months

Abstract

A novel transducer for immunosensing based on the dissolution of biodegradable polymer films as a direct result of an enzymatic reaction, will be developed. The rate of film dissolution is related to the enzyme concentration and will be measured by capacitance and QCM measurements. Using this system for immunosensing with the enzyme as a label provides a vastly improved measurement concept since no enzyme substrate needs to be added. The electrode coating itself serves as the substrate, thus making the electrode an integral part of the sensing process and reducing the number of washing steps otherwise required in standard immunoassay techniques. The function of the transducer will be demonstrated by detecting a clinically relevant analyte, FABP, an early marker of myocardial infarction.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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