Award details

Development of novel immunoglobulin-binding proteins for use in the affinity purification of antibodies fabs and single-chain Fv fragments

Reference	E11896
Principal Investigator / Supervisor	Professor Michael Gore
Co-Investigators / Co-Supervisors
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	135,644
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	31/03/2003
Duration	36 months

Abstract

The aim of the project is to produce a library of proteins that will act as affinity ligands for the purification of antibodies, antibody fragments and ScFv fragments (mini- antibodies) suitable for the present multi-million pound world market. These proteins and their genes will also find valuable uses in immunoassays and cloning vectors, respectively. The proteins will be based upon single or double Ig-binding domains of protein L and hybrid constructs formed between protein L, protein A and protein G domains engineered to have favourable binding and elution characteristics.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search