BBSRC Portfolio Analyser
Award details
Enzyme-catalysed acylation as a new strategy for oligosaccharide synthesis with minimal protection
Reference
E11765
Principal Investigator / Supervisor
Professor Benjamin Davis
Co-Investigators /
Co-Supervisors
Professor Antony Fairbanks
Institution
University of Oxford
Department
Dyson Perrins Laboratory
Funding type
Research
Value (£)
176,163
Status
Completed
Type
Research Grant
Start date
24/01/2000
End date
24/04/2002
Duration
27 months
Abstract
There still exists no generally applicable method for the efficient and stereoselective formation of glycosidic bonds. Whilst the tethering of glycosyl acceptors to glycosyl donors allows the formation of glycosidic bonds with a higher degree of stereocontrol, present approaches are hampered by laborious protection regimes. An approach to the tethering of unprotected donors and acceptors through the enzyme-catalysed regioselective formation of esters and mixed disulphide links is described. Suitable activation should allow the formation of glycosidic bonds, in a manner that readily lends itself to facile iteration. It is proposed that variations in the nature and length of the introduced tether will determine the stereochemistry of the newly formed anomeric centre.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search