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Design and implementation of aqueous two-phase partition for recovery of adenovirus gene therapy vectors
Reference
E11714
Principal Investigator / Supervisor
Professor Jonathan Seville
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Chemical Engineering
Funding type
Research
Value (£)
302,156
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
01/04/2003
Duration
41 months
Abstract
Aqueous two-phase partition systems (ATPS) will be mechanistically designed and implemented to facilitate the primary processing of crude cell culture lysates enriched with putative adenovirus gene therapy vectors. ATPS will be designed for robust performance in the face of varied qualities/quantities of feedstock biomass, and be compatible with upstream processes of cell culture and downstream operations of product fractionation, polishing and formulation. Systems will be quantitatively described, monitored and manipulated in respect of data recovered from novel analytical procedures which describe changes in phase diagrams promoted by added biomass. Performance will be critically compared with that of fluidised bed adsorption.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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