Award details

Synthesis and characterisation of novel betaine-based copolymers for high performance biocompatible coatings

Reference	E11449
Principal Investigator / Supervisor	Professor Andrew Lloyd
Co-Investigators / Co-Supervisors	Professor Richard Faragher, Professor Geoffrey Hanlon
Institution	University of Brighton
Department	Sch of Pharmacy & Biomolecular Sciences
Funding type	Research
Value (£)	216,921
Status	Completed
Type	Research Grant
Start date	01/10/1999
End date	01/01/2003
Duration	39 months

Abstract

Anti-adherent biocompatible coatings have a wide range of applications in reducing both bacterial adhesion to and fibrosis of medical implants. Preliminary work undertaken through a collaboration between the Drug Delivery & Biomaterials Group at the University of Brighton and the Sussex Polymer Group at the University of Sussex has shown that statistical poly(sulphobetaine) copolymers coatings with well- defined controlled molecular architectures reduce significantly the adherence of macrophages, fibroblasts and bacteria to material surfaces. The aim of this work is to extend these investigations to develop an understanding of the physicochemical and molecular parameters that determine the adherence of biomolecules to these copolymer coatings. The overall aim is to optimise the copolymer architecture in order to provide stable high performance biocompatible coatings. (Joint with grant E11450).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E11450 Synthesis and characterisation of novel betaine- based copolymers for high performance biocompatible coatings

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