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The dynamics of biomolecules at interfaces studied by pulsed-force atomic force microscopy
Reference
E11169
Principal Investigator / Supervisor
Professor Clive Roberts
Co-Investigators /
Co-Supervisors
Professor Martyn Davies
,
Professor Saul Tendler
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
177,508
Status
Completed
Type
Research Grant
Start date
08/02/1999
End date
08/08/2001
Duration
30 months
Abstract
We propose to utilise and refine pulsed-force atomic force microscopy (AFM), a novel oscillation form of AFM, to study biomolecular distribution, interaction and functionality at interfaces. The significant potential of AFM using modified probes to quantify and spatially locate individual biomolecular interactions is apparent, however, to realise this potential a more robust and faster data acquisition rate is required. We will demonstrate the potential of pulsed-force to provide such progress (e.g. x100 increase in data rate) through mapping of protein adhesion (biocompatibility) to micropatterned self-assembled monolayers and polymers and also specific receptor-ligand interactions.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
BioImaging (BI) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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