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Life and death of T-lymphocytes
Reference
E11096
Principal Investigator / Supervisor
Professor Nigel Burroughs
Co-Investigators /
Co-Supervisors
Professor David Rand
Institution
University of Warwick
Department
Mathematics
Funding type
Research
Value (£)
143,304
Status
Completed
Type
Research Grant
Start date
01/06/1999
End date
01/06/2002
Duration
36 months
Abstract
Mathematical modelling of T-cell IL2 dependent growth and death (cytokine deprivation and induced apoptosis) is proposed using physiologically structured population models, i.e. models that explicitly treat the variation of the IL2 receptor density with antigenic exposure. The importance and significance of modulating receptor density during an immune response will be examined, with particular emphasis on the balance between, and competing demands of, selection against cells that have undergone repeated proliferation with the positive selection of optimal responses; T-cells which proliferate under weaker IL2 requirements in the presence of antigen. Receptor density measurements (FACS) will be used in the comparison to experiment, thereby providing an interpretation and quantification of FACS profiles in terms of control mechanisms and signal noise.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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