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Award details
Bioprocess design: statistical analysis of inter- mediary metabolite production for the construction of feeds for maximising yields.
Reference
E10873
Principal Investigator / Supervisor
Professor Michael Bushell
Co-Investigators /
Co-Supervisors
Professor Claudio Avignone Rossa
Institution
University of Surrey
Department
Health and Medical Sciences
Funding type
Research
Value (£)
202,516
Status
Completed
Type
Research Grant
Start date
31/05/1999
End date
18/12/2002
Duration
43 months
Abstract
This proposal aims to develop a rapid protocol for influencing biosynthetic fluxes using fed batch culture without knowledge of the biosynthetic pathway or the necessity for genetic manipulation. Quantification of the production rates of intermediary metabolites followed by statistical analysis of their relationship with bioproduct formation rate will be used to design culture feeds using: a natural product with a known biosynthetic pathway (clavulanic acid) and a natural product where in the biosynthetic pathway is less well characterised (vancomycin).
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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