Award details

Cell separations in expanded beds

Reference	E10441
Principal Investigator / Supervisor	Professor Howard Chase
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Chemical Engineering and Biotechnology
Funding type	Research
Value (£)	180,248
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	01/04/2002
Duration	39 months

Abstract

This proposal involves the development of novel bioprocess technology for the separation of biological cells using perfluorocarbon-based adsorbents in expanded bed procedures. The combination of these recent developed technologies promises to be a powerful, but economic technique for cell separations, involving simple equipment that can readily be scaled up. The steps necessary to achieve this aim will involve: 1) synthesis of solid and emulsion adsorbent phases for the selective capture, by attachment of suitable affinity and ion-exchange ligands, of particular cell types. 2) use of these supports in expanded bed separations of cells (both microbial and mammalian); 3) optimisation of capture, washing and elution phases of such processes such that the performance and productivity of the separations are maximised and the viability of the separated cells is maintained.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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