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Deracemisation of racemic mixtures of amino acids alcohols and amines using enzymes in combination with chemical reagents
Reference
E10358
Principal Investigator / Supervisor
Professor Nicholas Turner
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
183,089
Status
Completed
Type
Research Grant
Start date
01/09/1998
End date
01/09/2001
Duration
36 months
Abstract
The aim of this project is to develop novel enzyme-based catalytic systems for the deracemisation of racemic mixtures of chiral compounds including amino acids, alcohols and amines. Deracemisation involves the conversion of a racemic mixture to the single enantiomer form and offers an extremely efficient and cost effective way of generating optically pure chiral intermediates. This proposal is based on initial work which has resulted in a method for the deracemisation of both cyclic and acyclic amino acids using D-amino acid oxidase in concert with sodium borohydride or sodium cyanoborohydride. We now wish to extend this methodology to 1) amino acids containing more than one stereogenic centre 2) L-amino acid oxidases and 3) a greater range of chemical reducing agents. Furthermore, we shall investigate the application of this deracemisation process to other flavin-dependent oxidases which should provide methods for the production of optically pure amines (amine oxidase) and alcohols (alcohol oxidase).
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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