Award details

An integrative approach to the development of a novel biomimetic keratoprosthesis

Reference	E10337
Principal Investigator / Supervisor	Professor Andrew Lloyd
Co-Investigators / Co-Supervisors	Professor Richard Faragher
Institution	University of Brighton
Department	Sch of Pharmacy & Biomolecular Sciences
Funding type	Research
Value (£)	177,861
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	31/10/2002
Duration	45 months

Abstract

The basic biology of the cornea poses fundamental challenges to the design of artificial cornea (Kpro) of which tissue assimilation and epithelial colonisation are the primary problems. Novel SPIN systems offer the potential to closely mimic the structure-function of living tissue matrices with regard to fundamental physical parameters. To achieve full biofunction the performance of any material must be optimised within the context of the appropriate cell-tissue interaction, an area previously understudied in biomaterial research. This requires novel corneal cell substrains and ex vivo techniques. The applicants thus seek support for a joint collaborative project which will utilise GFP-trackable corneal cells to evaluate in vitro biofunctionality in order to optimise SPIN polymer design for a novel prototype Kpro. (Joint project with 92/E10340).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E10340 An integrative approach to the development of a novel biomimetic keratoprosthesis

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