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Spatially controlled cell engineering: a strategy to control nervous tissue micro-architecture

Reference	E10147
Principal Investigator / Supervisor	Professor Kevin Shakesheff
Co-Investigators / Co-Supervisors	Professor Martyn Davies, Professor Clive Roberts, Professor Saul Tendler, Professor Philip Williams
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	157,752
Status	Completed
Type	Research Grant
Start date	02/11/1998
End date	01/02/2002
Duration	39 months

Abstract

Tissue development requires the spatial organisation of cells, via directed cell growth and cell-to-cell interactions. It is proposed that to bioengineer many tissues it will be necessary to mimic the body's own organisational principles. Specifically, in nerve regeneration it would be advantageous to construct matrix-to-glial cell and glial cell- to-neuron receptor interactions. To achieve this biomimicking we propose to fabricate cell-interactive biodegradable polymer scaffolds with precisely defined surface properties that can organise cell adhesion and growth on the micron-scale. This work will require multi-disciplinary research combining expertise in polymer synthesis, surface analysis, patterning technology and cell engineering.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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