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Novel single cell measurements in micromachined structures
Reference
E10134
Principal Investigator / Supervisor
Professor Jonathan Cooper
Co-Investigators /
Co-Supervisors
Dr P Cobbold
Institution
University of Glasgow
Department
Institute of Cancer Studies
Funding type
Research
Value (£)
233,004
Status
Completed
Type
Research Grant
Start date
01/04/1999
End date
02/02/2003
Duration
46 months
Abstract
The aim of this proposal is to integrate a novel microelectrochemical single cell technology with established optical methods in order to, for the first time, correlate intra- (and extra-) cellular ion fluxes (including e.g. Ca2+ and pH) with the production of other metabolites (e.g. either lactate or adenosine). To illustrate the potential of this measurement system, in a collaboration with Glaxo-Wellcome New Medicines Discovery Division, we will use myocyte pathophysiology as a model to explore the application of micromachining in developing miniaturised high density single cell screens for the discovery of new therapies for cardiac ischaemia.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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