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Development of an enzyme-catalysed desymmetrisation of prochiral ketones
Reference
E09803
Principal Investigator / Supervisor
Dr Andrew Carnell
Co-Investigators /
Co-Supervisors
Institution
University of Liverpool
Department
Chemistry
Funding type
Research
Value (£)
179,437
Status
Completed
Type
Research Grant
Start date
20/07/1998
End date
20/07/2001
Duration
36 months
Abstract
We wish to develop a novel biotransformation which uses readily available hydrolytic enzymes for the production of chiral enol esters from a symmetrical cyclic and bicyclic ketones. These enol esters are extremely useful for the synthesis of fine chemicals and pharmaceuticals. We have demonstrated the success (Tet Lett. 1997, 38, 7781) of this approach with the model compound 4-cyano-4- phenylcyclohexanone. We propose to establish optimum conditions for four classes of substrate, demonstrate the synthetic potential of the chiral enol esters and show that the process is amenable to scale up.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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