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Coalescent-based estimation of demographic parameters selection and genealogical structure in multilocus genetic data sets

Reference	E09788
Principal Investigator / Supervisor	Professor Peter Donnelly
Co-Investigators / Co-Supervisors	Professor D Goldstein
Institution	University of Oxford
Department	Statistics
Funding type	Research
Value (£)	117,518
Status	Completed
Type	Research Grant
Start date	01/09/1998
End date	01/09/2001
Duration	36 months

Abstract

Widely used estimators of population parameters ignore important demographic and genetic complexities. High-throughput screening methods provide genome-wide data sets that make possible simultaneous estimation of various population parameters and allow us to considerably relax the assumption of earlier approaches. Here we will develop new estimators of demography based on genome-wide patterns of variation at microsatellite loci, single nucleotide polymorphisms, unlinked sets of sequence data, and inter-allelic genealogies. Demographic estimators are of considerable inherent interest, but we also use them to develop new tests of selection and genealogical structure that do not assume an underlying demography, but rather estimate it based on unlinked variation.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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