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Theoretical investigation of novel electrophoretic techniques for the separation and analysis of DNA molecules
Reference
E08580
Principal Investigator / Supervisor
Professor Thomas Duke
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Physics
Funding type
Research
Value (£)
121,053
Status
Completed
Type
Research Grant
Start date
11/02/1998
End date
11/02/2001
Duration
36 months
Abstract
Microfabrication technology provides a new methodology for separating and analysing DNA molecules, which promises to supersede traditional gel-electrophoretic techniques. Using optical lithography, miniature electrophoretic chambers can be manufactured on a silicon chip. The design of obstacles and channels can be chosen at will. We propose to use a combination of theoretical analysis and numerical simulation to study the dynamics of DNA molecules migrating in these devices. We aim to identify designs optimally suited to particular separation tasks and determine the characteristics of the electrophoretic separation provided by each type of device. Theoretical results will be compared with videomicroscopy data from actual experiments.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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