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Wavefront correction in confocal microscopy
Reference
E08537
Principal Investigator / Supervisor
Professor Tony Wilson
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Engineering Science
Funding type
Research
Value (£)
182,917
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/2000
Duration
36 months
Abstract
A major problem in the confocal microscopy of thick biological tissue is that the resolution deteriorates and the signal level falls rapidly as the microscope is focussed into the specimen. This is unavoidable and is caused by refractive index mismatches. We intend to develop a system which both measures the wavefront aberration and uses active feedback to a phase correction element. This results in near diffraction limited imaging throughout the whole volume. The key element is a novel design of wavefront sensor with a particularly high signal to noise ratio and which also exhibits confocal sectioning. The system will be used to image biologically important tissue in collaboration with the Department of Pharmacology at Oxford.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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