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Modification of therapeutic protein products during viral-inactivation processes
Reference
E08102
Principal Investigator / Supervisor
Professor David James
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
165,931
Status
Completed
Type
Research Grant
Start date
17/11/1997
End date
31/01/2001
Duration
38 months
Abstract
Viricidal heat treatment of therapeutic protein preparations can result in protein modification(s) which are neo-antigenic resulting in the formation of neutralising antibodies in patients. This project will employ advanced protein analytical technology (chromatography, mass spectrometry, spectroscopy, nuclear magnetic resonance spectroscopy) to gain a thorough understanding of the modifications undergone by plasma-derived therapeutic proteins as a result of increasingly harsh high-temperature virucidal treatments used in industry. The antigenicity of these modifications will be assessed by state-of-the-art techniques (ELISA, SCID mice). This information will enable the development of improved viral-inactivation processes and monitoring procedures to assure protein product quality, and therefore the health and safety of those receiving treatment.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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