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Enzyme action under very low water conditions: hydration hysteresis and sulphatase reversal
Reference
E07298
Principal Investigator / Supervisor
Professor Peter James Halling
Co-Investigators /
Co-Supervisors
Dr George Bell
,
Dr Barry Moore
Institution
University of Strathclyde
Department
Bioscience
Funding type
Research
Value (£)
162,019
Status
Completed
Type
Research Grant
Start date
01/02/1997
End date
01/02/2000
Duration
36 months
Abstract
We will develop better understanding of hysteresis phenomena in the dependence of bound water content and catalytic activity on water activity. We will compare subtilisin and Candida rugosa lipase, in various catalyst forms, including support-adsorbed, cross-linked crystals and activity in various modes of application. The understanding gained will be exploited in an examination of the feasibility of reversing sulphatase action, so as to synthesise sulphate esters. This will require very low water and acidic media, with control of water activity and acid/base buffering.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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