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The study of biomolecular and biomedical systems by near-field optical microscopy
Reference
E06690
Principal Investigator / Supervisor
Professor Clive Roberts
Co-Investigators /
Co-Supervisors
Professor Martyn Davies
,
Professor Saul Tendler
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
141,709
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
28/06/2001
Duration
45 months
Abstract
Near-field optical probe microscopy (NSOM) is a new and exciting link between the utility of optical microscopy and spectroscopy and the high resolution capabilities of scanning probe microscopes. We propose to employ and develop NSOM as a biophysical tool. We will utilise and adapt the latest commercial NSOM/optical microscope system (Aurora II, Topometrix Corp.). We will develop NSOM probes with tailored characteristics and will provide a spectroscopic capability by interfacing the Aurora II to an existing spectrometer. Studies will centre on patterning biomolecular surfaces and single molecule fluorescence spectroscopy. In particular, NSOM will be used to examine antigen-antibody interactions and protein release from polymer systems.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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