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Microbial transformations of the morphine alkaloids
Reference
E04281
Principal Investigator / Supervisor
Professor Neil Bruce
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Institute of Biotechnology
Funding type
Research
Value (£)
140,690
Status
Completed
Type
Research Grant
Start date
11/09/1995
End date
11/09/1998
Duration
36 months
Abstract
The morphine alkaloids are an important group of naturally occurring compounds that provide some of the most potent analgesic and antitussive compounds. The majority of these drugs are synthesised, by chemical means, from morphine, codeine or thebaine obtained from the opium poppy. The aim of this project is to explore the metabolism of the morphine alkaloids in microorganisms. It is envisaged that a fundamental study of morphine metabolism will reveal new alkaloid metabolites with therapeutic value and will result in the discovery of new biological routes for the synthesis of opiate drugs, where existing synthetic processes are far from satisfactory.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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