Award details

SERC centre for biochemical engineering at Birmingham

Reference	E03398
Principal Investigator / Supervisor	Professor Colin Thomas
Co-Investigators / Co-Supervisors	Mr A Emery, Professor Alvin Nienow
Institution	University of Birmingham
Department	Chemical Engineering
Funding type	Research
Value (£)	1,456,644
Status	Completed
Type	Research Grant
Start date	01/10/1993
End date	01/10/1997
Duration	48 months

Abstract

The facilities and expertise of Centre staff, the synergy within the Centre, and multidisciplinary links within the University of Birmingham, are to be used to solve some outstanding problems of fundamental importance to the UK bioprocess industries. These are: (i) A priori design and optimal operation of industrial-scale mycelial fermentations is unreliable because of inadequate knowledge of the behaviour of highly-viscous non-Newtonian fermentation broths in fermenters; (ii) There are engineering constraints on the design and operation of intensive processes for the production of recombinant and other protein products from animal cell culture, both in scale-up and process intensification, and in the maintenance of acceptable product quality and yield; (iii) Solid-liquid separation by centrifugation or microfiltration commonly provides inadequate clarification and fractionation in processes designed for the recovery of intracellular proteins or cellular components; and (iv) Direct integration of selective adsorption with fermentation reactors will facilitate increased yields of extracellular products but is compromised by poor understanding of design and operation of contactors compatible with suspension feedstocks.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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