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Characterisation and improvement of Baeyer-Villiger mono-oxygenase enzymes as biocatalysts for key reactions in chemoenzymatic syntheses
Reference
E02782
Principal Investigator / Supervisor
Dr A Willetts
Co-Investigators /
Co-Supervisors
Professor Stanley Roberts
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
319,378
Status
Completed
Type
Research Grant
Start date
01/11/1994
End date
01/11/1997
Duration
36 months
Abstract
1. Characterisation of the two enantiodivergent NADH-dependent diketocamphane mono-oxygenase isoenzymes from Pseudomonas putida NCIMB 9871 (specificity, active site models, X-ray analysis of crystals). 2. Overexpression of the two mono-oxygenase isoenzymes from NCIMB 10007 and modification by SDM to change aspects of specificity. Use of either native or modified enzymes to produce a number of insect pheromones by biotransformation. 3. As 1 and 2 for NADH-dependent Baeyer-Villiger mono-oxygenase from Hydrogenophaga flava UQM 1742. 4. As 1 and 2 for NADH-dependent cyclohexanone mono-oxygenase from Acinetobacter calcoaceticus NCIMB 9871.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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