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Cytoprotective effects of dietary flavonoids and their metabolites through modulation of signalling and gene expression
Reference
D20463
Principal Investigator / Supervisor
Dr Robert Williams
Co-Investigators /
Co-Supervisors
Professor Marcus Rattray
,
Dr C Rice-Evans
,
Professor Jeremy Spencer
Institution
King's College London
Department
Sch of Biomolecular Sciences
Funding type
Research
Value (£)
236,371
Status
Completed
Type
Research Grant
Start date
01/08/2004
End date
31/10/2007
Duration
39 months
Abstract
In vivo forms of flavonoid conjugates and metabolites are unlikely to act as conventional hydrogen-donating antioxidants. Flavonoids may be cytoprotective through the recruitment of intracellular signalling pathways and consequent regulation of gene expression to increase cellular defences. To test this hypothesis, we shall use biochemical and molecular biological approaches to determine the potency and selectivity of key dietary flavonoids and their in vivo metabolites on regulation of several important cell signalling proteins, transcriptional activation and gene expression of potentially protective substances. The activity of flavonoids will be correlated with their ability to afford cellular protection against oxidative stress.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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