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Molecular investigation of mechanisms of copper homeostasis in humans
Reference
D20457
Principal Investigator / Supervisor
Professor Susan Jane Fairweather-Tait
Co-Investigators /
Co-Supervisors
Dr Ruan Elliott
,
Dr Linda Harvey
Institution
Quadram Institute Bioscience
Department
Nutrition Division
Funding type
Research
Value (£)
195,079
Status
Completed
Type
Research Grant
Start date
01/01/2004
End date
31/03/2007
Duration
39 months
Abstract
Copper is an essential cofactor in many biological processes including respiration and iron metabolism. In humans the absorption and excretion of copper is regulated to maintain balance, but there is little information on the genetic control of these homeostatic mechanisms. The optimal range of intake is not clear, nor is it possible to predict the risk of copper-associated diseases due to the lack of status biomarkers. No other studies have comprehensively measured gene transcription and translation in order to determine the control mechanisms of copper homeostasis in human cells. This project aims to define the genetic regulation of copper homeostasis at different levels of exposure and to identify novel biomarkers of copper status.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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