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Pro-inflammatory response to Campylobacter and heat-stable Campylobacter products
Reference
D20452
Principal Investigator / Supervisor
Professor Ian Connerton
Co-Investigators /
Co-Supervisors
Dr Kenneth Mellits
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
243,297
Status
Completed
Type
Research Grant
Start date
01/11/2003
End date
31/10/2006
Duration
36 months
Abstract
Human colonic epithelial cells respond to Campylobacter jejuni by activation of the transcription factor NF-kB to induce innate immunity and switch on pro-inflammatory cytokines. C. jejuni cell components stable to heat treatment constitute a potent activator of NF-kB leading to the efficient induction of cytokines/chemokines including interleukin-8. We propose to characterise the bioactive components of Campylobacters and examine human gut epithelial cell responses to these products.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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