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Transcriptional regulation of human colonic butyrate transporter MCT1; a molecular analysis

Reference	D20142
Principal Investigator / Supervisor	Professor Soraya Shirazi-Beechey
Co-Investigators / Co-Supervisors	Dr Mark Cuff
Institution	University of Liverpool
Department	Veterinary Preclinical Science
Funding type	Research
Value (£)	217,898
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	31/12/2006
Duration	39 months

Abstract

Butyrate, a product of colonic fermentation of dietary fibre and starch, regulates expression of genes important to the homeostasis of the colonic mucosa. Butyrate is transported across the colonic luminal membrane by the monocarboxylate transporter, MCT1. We have demonstrated that expression of MCT1 i) is regulated by its substrate butyrate, and ii) declines in colon carcinoma. We shall investigate the molecular mechanisms underlying the butyrate-induced transcriptional regulation of MCT1. We shall use a range of molecular techniques to identify the specific cis-acting elements and the transcription factors with which they interact. We shall assess the relevance of these findings to MCT1 transcription in native colonic tissue.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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