BBSRC Portfolio Analyser
Award details
ShdA-mediated intestinal persistence of Salmonella typhimurium
Reference
D20084
Principal Investigator / Supervisor
Dr Katherine Brown
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
217,221
Status
Completed
Type
Research Grant
Start date
01/12/2004
End date
30/06/2008
Duration
43 months
Abstract
Salmonella is a major cause of economic loss. ShdA is a surface protein of Salmonella that mimics heparin, binding a cationic cradle of the Hep-2 domain of fibronectin (Fn). Deletion of ShdA results in reduced colonisation. ShdA binding to Fn will be characterised in vitro and in vivo. The minimal region of ShdA required for binding Fn and the role in colonisation will be identified. We will investigate the role of ShdA binding to Fn in ShdA mediated persistence of S. typhimurium in the intestine. The role of intestinal persistence in the immune response of the host to infection by Salmonella will be investigated to evaluate vaccine strains containing a deletion of shdA. ShdA domains will be expressed for crystalisation studies.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
Animal Health, Immunology, Microbial Food Safety, Microbiology, Structural Biology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search