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Characterisation of Salmonella immunogens
Reference
D20030
Principal Investigator / Supervisor
Professor Maurice Gallagher
Co-Investigators /
Co-Supervisors
Professor Judith Allen
,
Dr Christopher Inchley
Institution
University of Edinburgh
Department
Inst of Structural and Molecular Biology
Funding type
Research
Value (£)
250,426
Status
Completed
Type
Research Grant
Start date
20/04/2004
End date
19/10/2007
Duration
42 months
Abstract
We have used 2D gels and phage biopanning to identify immunogens which are seen during murine infection with Salmonella typhimurium. We now propose to clone, overexpress and affinity purify a selection of these proteins and also, known adhesins (approx. 100 proteins) and, to evaluate their immunological importance in the humoral and cell mediated immunity which arises during infection of mice and calves. Using inbred/congenic mice, the importance of host genetic background on polypeptide recognition will also be addressed and the potential of a selection of the antigens to elicit protective immunity against virulence challenge will be examined. The study will provide evidence for the value of the antigens as potential vaccine components.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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