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Monitoring phagosomal metal levels during Salmonella infection
Reference
D19920
Principal Investigator / Supervisor
Dr Jennifer Cavet
Co-Investigators /
Co-Supervisors
Dr Anjam Khan
,
Professor Nigel Robinson
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
205,944
Status
Completed
Type
Research Grant
Start date
01/06/2004
End date
31/05/2007
Duration
36 months
Abstract
Salmonella enterica serovar Typhimurium is of major importance as a foodborne pathogen. Competition for essential metals (such as iron) is a crucial determinant of its pathogenicity. However, there is growing support for a model in which sudden exposure to redox active metals, accompanied by a sudden deadly change in the nature of reactive oxygen species, contributes to the killing of this pathogen in late endosomes. This project will test the model.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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