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The molecular basis to Escherichia coli O157:H7 colonisation of the terminal rectum in cattle
Reference
D19613
Principal Investigator / Supervisor
Professor David Gally
Co-Investigators /
Co-Supervisors
Dr Christopher Low
,
Professor David Smith
Institution
University of Edinburgh
Department
Veterinary Biomedical Sciences
Funding type
Research
Value (£)
247,128
Status
Completed
Type
Research Grant
Start date
01/12/2003
End date
31/01/2007
Duration
38 months
Abstract
Our research has recently defined the principle colonisation site of enterohaemorrhagic Escherichia coli O157 in cattle. EHEC O157 has a novel and exquisite tropism for the final few centimetres of the terminal rectum, proximal to the recto-anal junction. This region is characterised by a high density of lymphoid follicles. The aim of the research is to define the bacterial and host factors that are responsible for this tropism. In vitro methods will be developed that will allow both random and defined EHEC O157 mutants to be tested for loss of the tropism. This will be complemented by characterisation of this anatomical site for epithelial differences that may explain this specific and important localisation within the gastrointestinal tract.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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