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Interrogating the acetylome: human health through hyperacetylation in the colon
Reference
D19346
Principal Investigator / Supervisor
Professor Bernard Corfe
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Division of Clinical Sciences North
Funding type
Research
Value (£)
294,508
Status
Completed
Type
Research Grant
Start date
14/07/2003
End date
13/09/2006
Duration
38 months
Abstract
There is an inverse correlation between butyrate levels in the colon, produced by fermentation of dietary fibre, and incidence of colorectal cancer. Butyrate is both a fuel source for colonocytes and a histone deacetylase inhibitor at physiological doses. Colonic enterocytes are therefore likely to have a highly acetylated proteome and this may contribute to bowel health. We will identify the extent of protein acetylation in the proteome of cells cultured with butyrate. We will identify the constituents of the acetylome by mass spectrometry. Thus changes in the colonic proteome as a direct response to diet will be identified. Study of the role of acetylation of specific targets may yield novel biomarkers of diet and health.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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