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Role of Salmonella pathogenicity island 4 in colonisation of cattle by Salmonella typhimurium
Reference
D19269
Principal Investigator / Supervisor
Professor Mark Stevens
Co-Investigators /
Co-Supervisors
Dr Eirwen Morgan
Institution
The Pirbright Institute
Department
Div of Microbiology Compton
Funding type
Research
Value (£)
189,152
Status
Completed
Type
Research Grant
Start date
17/05/2003
End date
16/05/2006
Duration
36 months
Abstract
Salmonella typhimurium causes severe enteric and systemic disease in farm animals which act as a reservoir for human infections. We have demonstrated that Salmonella Pathogenicity Island -4 (SPI-4) is required for the initial colonisation of the bovine gastro-intestinal tract by S. typhimurium. We aim to determine how SPI-4 influences colonisation and pathogenesis through the integration of molecular genetic techniques with in vivo and in vitro analyses of S. typhimurium interactions with bovine cells. We will also investigate the distribution of functional SPI-4 genes in different Salmonella serotypes and will assess the potential of SPI04 as a candidate for vaccine development.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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