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Signalling Role of Adipose Tissue - Regulation of fasting-induced adipose factor a novel secretory protein
Reference
D19063
Principal Investigator / Supervisor
Professor Paul Trayhurn
Co-Investigators /
Co-Supervisors
Institution
University of Liverpool
Department
Neuroendocrine & Obesity Biology Unit
Funding type
Research
Value (£)
173,164
Status
Completed
Type
Research Grant
Start date
01/08/2003
End date
31/07/2006
Duration
36 months
Abstract
White adipose tissue is a key endocrine organ, secreting leptin and other signals. A novel secretory signal, fasting-induced adipose factor, or FIAF, has recently been identified which may have opposing action to leptin. The goal of this project is to elucidate the principal factors - nutritional, hormonal, neural - which regulate expression of the FIAF gene and the production of the protein. The proposition that FIAF is regulated reciprocally to leptin, particularly by the sympathetic system, will be tested. A combination of in vivo (mice) and adipocyte cell culture (rodent, human) studies will be performed. The project will help elucidate the role of FIAF and of white fat in energy balance and metabolic regulation.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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