Award details

Exosporium proteins and the fine structure of the bacterial endospore surface

Reference	D18848
Principal Investigator / Supervisor	Professor Anne Moir
Co-Investigators / Co-Supervisors	Professor Per Bullough
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	406,484
Status	Completed
Type	Research Grant
Start date	01/03/2003
End date	30/11/2006
Duration	45 months

Abstract

Bacillus cereus is a food pathogen, and its spores are food contaminants. The outer spore surface, or exosporium, layer of B. cereus confers adhesion properties and antigenicity. The paracrystaline protein array of the exosporium will be defined at high resolution in both wild type and selected mutants by electron cryomicroscopy. The location and role of recently identified novel proteins of exosporium (including their assembly) will be determined by gene inactivation, Western blotting, and antibody labelling. An understanding of the exosporium will inform studies of spore surface properties of B. cereus, and also B. thuringiensis, B. anthracis and, in general, the many other spore formers, including Clostridia, that have an exosporium.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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