Award details

Exosporium proteins and the fine structure of the bacterial endospore surface

ReferenceD18848
Principal Investigator / Supervisor Professor Anne Moir
Co-Investigators /
Co-Supervisors
Professor Per Bullough
Institution University of Sheffield
DepartmentMolecular Biology and Biotechnology
Funding typeResearch
Value (£) 406,484
StatusCompleted
TypeResearch Grant
Start date 01/03/2003
End date 30/11/2006
Duration45 months

Abstract

Bacillus cereus is a food pathogen, and its spores are food contaminants. The outer spore surface, or exosporium, layer of B. cereus confers adhesion properties and antigenicity. The paracrystaline protein array of the exosporium will be defined at high resolution in both wild type and selected mutants by electron cryomicroscopy. The location and role of recently identified novel proteins of exosporium (including their assembly) will be determined by gene inactivation, Western blotting, and antibody labelling. An understanding of the exosporium will inform studies of spore surface properties of B. cereus, and also B. thuringiensis, B. anthracis and, in general, the many other spore formers, including Clostridia, that have an exosporium.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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